11-Deoxy-Beta-Rhodomycin

11-Deoxy-Beta-Rhodomycin is a small molecule anthracycline antibiotic derivative involved in the biosynthesis of the polyketide antibiotic beta-rhodomycin and aclacinomycin. It lacks the phenolic hydroxy group at position 11 compared to beta-rhodomycin. This compound is part of an aromatic polyketide class exhibiting high cytotoxicity and has relevance in chemotherapy research due to its antineoplastic properties. Mechanistically it participates as a substrate in enzymatic hydroxylation reactions catalyzed by Aclacinomycin 10-hydroxylase (RdmB), which uses S-Adenosyl-L-methionine as a cofactor for hydroxylation at C-10 position during biosynthesis pathways. The enzyme catalyzing its transformation does not require typical cofactors like flavins or metal ions for oxygen activation.

Other names

CHEBI:85897(1S,3R,4R)-3-ethyl-3,4,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranoside(7S,9R,10R)-7-((2R,4S,5S,6S)-4-(dimethylamino)-5-((2S,...