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Drug intelligence / Profile preview
11-valent Streptococcus pneumoniae conjugate vaccine
- Development stage
- Phase 1
- Lead developer
- GSK
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
The 11-valent Streptococcus pneumoniae conjugate vaccine is an investigational pneumococcal conjugate vaccine (PCV) developed by GlaxoSmithKline Biologicals (GSK). It is composed of 11 pneumococcal capsular polysaccharide serotypes (1, 3, 4, 5, 6B, 7F, 9V, 14, 18C, 19F, and 23F) conjugated to carrier proteins, primarily Protein D (PD) derived from non-typeable Haemophilus influenzae, and Diphtheria Toxoid (DT) for serotypes 6B and 23F. The vaccine is designed to stimulate an active immune response against Streptococcus pneumoniae infections, including pneumonia and invasive pneumococcal disease. It has been evaluated in Phase I/II clinical trials in healthy, pneumococcal vaccine-naive elderly adults (aged 65–85 years) to assess safety, reactogenicity, and immunogenicity, often utilizing novel adjuvant systems to enhance the immune response in this population.
- Other names
- 11vPCV11-valent pneumococcal conjugate vaccine11Pn-PDPCV11PCV-11PCV 11
02
Targets
PD (Protein D)SpCPS1 (Streptococcus pneumoniae capsular polysaccharide serotype 1)CPS14 (Streptococcus pneumoniae capsular polysaccharide serotype 14)CPS 18C (Streptococcus pneumoniae capsular polysaccharide serotype 18C)CPS19F (Streptococcus pneumoniae capsular polysaccharide serotype 19F)CPS23F (Streptococcus pneumoniae capsular polysaccharide serotype 23F)PPS3 (Streptococcus pneumoniae serotype 3 capsular polysaccharide)CPS4 (Streptococcus pneumoniae capsular polysaccharide serotype 4)PPS5 (Streptococcus pneumoniae capsular polysaccharide serotype 5)6B CPS (Streptococcus pneumoniae serotype 6B capsular polysaccharide)7F CPS (Streptococcus pneumoniae serotype 7F capsular polysaccharide)Streptococcus pneumoniae capsular polysaccharide serotype 9V (PnPS 9V)
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