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111-indium-CMD-193
- Development stage
- Discontinued
- Lead developer
- Pfizer
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
111-indium-CMD-193 is a radiolabeled antibody-drug conjugate composed of CMD-193 (a humanized monoclonal antibody targeting the Lewis Y antigen) conjugated to the cytotoxic agent calicheamicin and labeled with the radioisotope indium-111. The radiolabel allows for detection of the drug's biodistribution and tumor localization using gamma scintigraphy. CMD-193 specifically binds to tumors expressing the Lewis Y antigen, delivering both targeted cytotoxicity via calicheamicin and enabling imaging through indium-111. The drug was developed for use in patients with advanced cancers expressing Lewis Y antigen but showed rapid blood clearance and increased hepatic uptake with low tumor accumulation in clinical studies[1][2][5]. Myelosuppression and liver function effects were notable adverse events[5]. Development has been discontinued.
- Other names
- indium In 111-CMD-193indium In 111 hu3S193-calicheamicin conjugate
02
Targets
LeY (Lewis Y antigen)
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