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111In-amIgG-TAT
- Development stage
- Unknown
- Lead developer
- University of Oxford
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
- Administration
- Intravenous
01
Overview
111In-amIgG-TAT is a control radioimmunoconjugate consisting of an anti-mouse IgG (amIgG) monoclonal antibody conjugated to the cell-penetrating peptide TAT (transactivator of transcription) and radiolabeled with indium-111 (111In) via a diethylenetriaminepentaacetic acid (DTPA) chelator. Developed by researchers at the University of Oxford, it is used as a non-targeting control in preclinical studies evaluating gamma-H2AX-targeted radioimmunoconjugates (such as 111In-anti-gamma-H2AX-TAT) for molecular radiation therapy and imaging of DNA double-strand breaks in cancer models.
- Other names
- 111In-DTPA-amIgG-TAT111In-DTPA-mIgG-TAT111In-mIgG-TATIndium-111 anti-mouse IgG-TATIndium111 anti-mouse IgG-TATIndium 111 anti-mouse IgG-TAT
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