111In-DOTA-anti-CEA minibody

111In-DOTA-anti-CEA minibody is a radiolabeled antibody fragment used in preclinical research for tumor imaging. It consists of the T84.66 minibody, an engineered anti-carcinoembryonic antigen (CEA) fragment (scFv-CH3 dimer) with a molecular weight of approximately 80 kDa. The minibody is conjugated with the chelator DOTA (1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid) and labeled with the radioisotope indium-111 (111In). This biologic imaging agent is designed to provide rapid tumor targeting and efficient blood clearance compared to intact antibodies, making it suitable for radioimmunoscintigraphy (RIS) of CEA-positive tumors. Research studies, including biodistribution and imaging in mouse xenograft models of human colorectal cancer, have been conducted at institutions such as the City of Hope National Medical Center.

Other names

111In-DOTA-T84.66 minibodyIndium-111 DOTA-anti-CEA minibodyIndium111 DOTA-anti-CEA minibodyIndium 111 DOTA-anti-CEA minibody111In-labeled T84.66 minibody