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111In-DTPA-IL1RAP
- Development stage
- Preclinical
- Lead developer
- Centre Georges-François Leclerc
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Gamma Emitters → Radiopharmaceuticals, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
111In-DTPA-IL1RAP is a radiopharmaceutical imaging probe consisting of an anti-interleukin-1 receptor accessory protein (IL-1RAP) monoclonal antibody (clone B-L43) conjugated with diethylene triamine pentaacetic acid (DTPA) and radiolabeled with the gamma-emitting radionuclide Indium-111 (111In). Developed as a theranostic agent, 111In-DTPA-IL1RAP is designed for single-photon emission computed tomography (SPECT) imaging to detect IL-1RAP-positive hematological malignancies, such as acute myeloid leukemia (AML). It serves as a companion diagnostic to select patients and monitor target expression for anti-IL-1RAP chimeric antigen receptor (CAR) T-cell therapies.
- Other names
- 111In-DTPA-IL-1RAP111In-IL1RAPIndium-111 DTPA-IL1RAPIndium111 DTPA-IL1RAPIndium 111 DTPA-IL1RAP
02
Targets
IL1RAP (Interleukin 1 receptor accessory protein)
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