Drug intelligence / Profile preview

111In-DTPA-ITGA6B4

Development stage: Preclinical
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intravenous

Overview

111In-DTPA-ITGA6B4 is a radiolabeled monoclonal antibody used as an immuno-SPECT imaging probe that targets integrin α6β4, a cell-surface receptor overexpressed in certain human cancers such as pancreatic adenocarcinoma. The conjugate consists of a monoclonal antibody (ITGA6B4) against integrin α6β4, chelated with diethylenetriamine pentaacetic acid (DTPA), and labeled with the gamma-emitting radioisotope indium-111 (111In). Upon intravenous administration, 111In-DTPA-ITGA6B4 selectively binds tumors with high expression of integrin α6β4 and can be visualized by single-photon emission computed tomography (SPECT), making it a tool for non-invasive tumor imaging and localization in preclinical cancer models[2][5].

Other names: 111In-DTPA-ITGA6B4

Targets

α6β4 (Integrin alpha-6 beta-4)

Beyond the preview

Go deeper on 111In-DTPA-ITGA6B4.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on 111In-DTPA-ITGA6B4.

Explore the full profile