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11C-labeled thymine-carborane conjugates
- Development stage
- Preclinical
- Lead developer
- RIKEN
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
11C-labeled thymine-carborane conjugates are a class of carbon-11 radiolabeled thymidine and 4'-thiothymidine derivatives conjugated with carborane clusters, developed by RIKEN and the National Center for Geriatrics and Gerontology for PET imaging-guided boron neutron capture therapy (BNCT). These conjugates are designed to target thymidine kinase 1 (TK1), an enzyme highly expressed in proliferating cancer cells. By combining the tumor-targeting capability of thymidine analogs with the high boron content of carboranes, these agents serve as theranostic tools to non-invasively evaluate the biodistribution of boron agents in vivo and optimize the spatiotemporal parameters of neutron-beam irradiation during BNCT.
- Other names
- 11C-labeled 4'-thio-thymidine carborane conjugates11C-labeled thymidine carborane conjugates
02
Targets
TK1 (Thymidine kinase 1)
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