11C-PBR28 + 18F-Florbetaben

This is a combination of two PET radiotracers used in neuroimaging research, particularly for Alzheimer's disease and related neurodegenerative disorders. **11C-PBR28** is a second-generation radioligand that binds to the translocator protein (TSPO), which is upregulated in activated microglia, serving as a marker of neuroinflammation. **18F-florbetaben** is a fluorine-18 labeled stilbene derivative that binds specifically to β-amyloid plaques in the brain, allowing visualization and quantification of amyloid pathology. The combination enables simultaneous or sequential assessment of both amyloid deposition and neuroinflammation within the same subjects using PET imaging. This dual-tracer approach provides complementary information about two key pathological processes in Alzheimer's disease: amyloid accumulation and microglial activation[2][5][9].

Brand names

Neuraceq (for florbetaben F18)

Other names

[11C]PBR28[18F]florbetabenflorbetaben F18