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11C-yohimbine
- Development stage
- Phase 1
- Lead developer
- Johns Hopkins University
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
11C-yohimbine is a radiopharmaceutical used as a Positron Emission Tomography (PET) tracer to image and quantify alpha-2 adrenergic receptors in the brain and peripheral tissues. It is a carbon-11 labeled version of yohimbine, a natural alkaloid that acts as a potent and selective alpha-2 adrenergic receptor antagonist. By binding to these receptors, 11C-yohimbine allows researchers to study the density and distribution of alpha-2 receptors in vivo, which is relevant for investigating various neuropsychiatric and cardiovascular conditions, including depression, anxiety, and hypertension. The tracer is primarily used in clinical research settings rather than routine diagnostic practice.
- Other names
- carbon-11 yohimbinecarbon11 yohimbinecarbon 11 yohimbine[11C]-yohimbine11C-labeled yohimbine
02
Targets
ADRA2B (α2B)ADRA2A (α2A)ADRA2C (α2C)
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