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123I-DualFAPi-5
- Development stage
- Preclinical
- Lead developer
- TetraKit Technologies
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
123I-DualFAPi-5 is a diagnostic radiopharmaceutical developed by TetraKit Technologies for the imaging of fibroblast activation protein (FAP)-expressing tumors. It consists of a FAP inhibitor (FAPi) dimer (DualFAPi-5) labeled with the gamma-emitting radioisotope iodine-123 (123I) using TetraKit's proprietary tetrazine-based click chemistry platform. Designed to prolong tumor residence time and improve tumor-to-background ratios, 123I-DualFAPi-5 is utilized as a diagnostic imaging agent for single-photon emission computed tomography (SPECT) to detect FAP-expressing tumors, such as triple-negative breast cancer (TNBC). It is being developed as a diagnostic companion or imaging counterpart to therapeutic radiohalogenated agents like 131I-DualFAPi-5 and 211At-DualFAPi-5.
- Other names
- DualFAPi
02
Targets
FAP (Fibroblast activation protein alpha)
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