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124I-18B10

Development stage: Unknown
Lead developer: Peking University Cancer Hospital & Institute
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intravenous

Overview

124I-18B10 is an investigational **radiolabeled humanized monoclonal antibody** PET imaging agent designed for gastrointestinal tumors that overexpress Claudin 18.2. It consists of the humanized anti-CLDN18.2 antibody 18B10 labeled with iodine-124, enabling noninvasive positron emission tomography visualization of CLDN18.2-positive lesions. The agent has been studied in a phase 0 setting as a molecular imaging biomarker to identify patients who may benefit from CLDN18.2-targeted therapies and to support efficacy evaluation; thyroid blockade with iodine is used during imaging to reduce physiologic thyroid uptake of free radioiodine.

Other names: iodine-124 labeled 18B10iodine124 labeled 18B10iodine 124 labeled 18B10124I-labeled 18B10124I radiolabeled humanized anti-CLDN18.2 monoclonal antibody 18B10

Targets

Claudin 18.2

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