124I-cRGDY-PEG-C dots

**124I-cRGDY-PEG-C dots** are hybrid core-shell silica nanoparticles developed for multimodal molecular imaging, specifically positron emission tomography (PET) and optical imaging. The particles have a Cy5 fluorescent dye at their core, are coated with poly(ethylene glycol) (PEG), and are surface-modified with cRGDY peptide ligands, targeting αvβ3 integrin receptors, which are overexpressed in many tumor types. Radiolabeled with iodine-124 (^124I), these nanoparticles enable sensitive, quantitative PET imaging for cancer diagnosis, staging, and potentially intraoperative guidance. Their mechanism relies on active molecular targeting of integrin-expressing tumors, preferential accumulation at disease sites, and rapid renal clearance, minimizing non-specific uptake and systemic exposure. They are under clinical investigation for imaging in metastatic melanoma and sentinel lymph node mapping[1][2][3].

Other names

Cornell dots124I-C dots124I-cRGDY–PEG–C dots