124I-humanized 3F8

**124I-humanized 3F8** is a radioimmunoconjugate composed of the humanized monoclonal antibody hu3F8 labeled with the positron-emitting isotope iodine-124. The hu3F8 antibody specifically targets GD2, a disialoganglioside highly expressed on neuroblastoma and other tumors such as melanoma and sarcoma. By binding to GD2 on tumor cells, the radiolabeled antibody enables PET imaging for tumor localization and dosimetry assessment. The humanization of the original murine (mouse-derived) 3F8 reduces immunogenicity in humans while retaining high affinity for GD2[1][2][5]. This agent is primarily used as an imaging tool in clinical trials to evaluate biodistribution and pharmacokinetics in patients with neuroblastoma and other solid tumors[2]. The underlying mechanism involves specific antigen targeting by the antibody component (hu3F8), combined with radioactivity from iodine-124 for PET-based detection.

Other names

iodine-124 humanized 3F8iodine124 humanized 3F8iodine 124 humanized 3F8I-124-hu3F8I124-hu3F8I 124-hu3F8iodine I-124 monoclonal antibody hu3F8