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124I-IAZGP
- Development stage
- Unknown
- Lead developer
- Weill Cornell Medicine
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
124I-IAZGP is a **radiopharmaceutical imaging agent** consisting of iodoazomycin galactopyranoside labeled with the positron-emitting isotope iodine-124. It is designed for **positron emission tomography (PET) imaging of tissue hypoxia**. The agent selectively accumulates in hypoxic cells, allowing noninvasive visualization of hypoxic regions in tumors. In preclinical studies, 124I-IAZGP demonstrated positive correlation with established hypoxia markers. In clinical studies, it was found to be safe in humans but did not show sufficient tumor uptake to justify clinical use. Primary indications studied were **advanced colorectal cancer** and **head and neck cancer**[1][3][4].
- Other names
- 124I-iodoazomycin galactopyranoside
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