124I-PEG-AVP0458 diabody

124I-PEG-AVP0458 diabody is a radiolabeled, pegylated antibody fragment (diabody) developed by Avipep Pty Ltd for the PET imaging of tumors expressing tumor-associated glycoprotein 72 (TAG-72). Derived from the scFv domains of the murine monoclonal antibody CC49, the diabody is site-specifically pegylated to optimize its pharmacokinetic profile, balancing rapid tumor penetration with reduced renal clearance. The construct is trace-labeled with the positron-emitting isotope Iodine-124 (124I). TAG-72 is a high-molecular-weight mucin-like glycoprotein overexpressed in various adenocarcinomas, including ovarian and prostate cancers. In Phase I clinical trials, 124I-PEG-AVP0458 demonstrated high specificity and rapid tumor targeting with minimal uptake in normal organs, supporting its development as a diagnostic tool and a potential theranostic platform for delivering therapeutic radionuclides.

Brand names

Avibody

Other names

124I-labeled pegylated CC49 diabodyAvibody