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125I-G250

Development stage: Preclinical
Lead developer: Heidelberg Pharma
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intravenous

Overview

125I-G250 is a radiolabeled monoclonal antibody consisting of the murine antibody G250 conjugated to the radioisotope iodine-125. G250 targets carbonic anhydrase IX (CAIX), a cell surface antigen highly expressed in clear cell renal cell carcinoma (ccRCC). The drug is primarily indicated for radioimmunodetection and radioimmunotherapy of renal cell carcinoma. The mechanism of action involves binding of the G250 antibody to CAIX on tumor cells, allowing specific delivery of the radioactive iodine-125 to the tumor. This results in emission of ionizing radiation locally at the cancer site, thereby enabling targeted imaging and potential cytotoxicity.

Other names: iodine-125 labeled G250iodine125 labeled G250iodine 125 labeled G250125I-girentuximab

Targets

CA9 (Carbonic anhydrase IX)

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