Drug intelligence / Profile preview

13-acetylphorbol

Development stage
Unknown
Modality
Nucleic Acid-Directed Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
01

Overview

**13-Acetylphorbol** is a naturally occurring organic compound classified as a phorbol ester, specifically an acetylated derivative of the diterpene phorbol. It is found in certain plant species such as *Croton tiglium*. Phorbol esters are known for their biological activity, notably as potent activators of protein kinase C (PKC), which plays a key role in cell signaling pathways related to proliferation, differentiation, and apoptosis. Due to its strong irritant properties and ability to modulate PKC activity, compounds like 13-acetylphorbol have been widely used in biomedical research but are not approved pharmaceuticals or dietary supplements[1][2][6].

Other names
phorbol 13-acetatephorbol13-acetatephorbol-13-acetatephorbol 13-monoacetatephorbol13-monoacetatephorbol-13-monoacetatephorbol 13-acetic acidphorbol13-acetic acidphorbol-13-acetic acid
02

Targets

PRKCA (Protein kinase C alpha)

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