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13-cis-retinoic acid + temozolomide
- Development stage
- Phase 2
- Lead developer
- North American Brain Tumor Consortium
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination therapy consisting of 13-cis-retinoic acid (cRA) and temozolomide (TMZ). 13-cis-retinoic acid is a metabolite of Vitamin A that induces cell differentiation, apoptosis, and inhibits cell proliferation. Temozolomide is an oral alkylating agent. This combination has been studied primarily for the treatment of recurrent malignant gliomas, showing improved progression-free survival compared to single-agent treatments in some clinical trials.
- Other names
- cRA + TMZisotretinoin + temozolomideaccutane + temozolomide
02
Targets
DNARARA (Retinoic acid receptor alpha)RXRA (Retinoid X receptor alpha)RAR (Retinoic acid receptor)
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