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Drug intelligence / Profile preview
131I-anti-TLR5 monoclonal antibody
- Development stage
- Preclinical
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Beta-minus Emitters → Radiopharmaceuticals, Gamma Emitters → Radiopharmaceuticals, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
131I-anti-TLR5 monoclonal antibody is a **radioiodinated monoclonal antibody** targeting **Toll-like receptor 5 (TLR5)**, which is overexpressed in several cancers, particularly hepatocellular carcinoma. It is primarily investigated as a radiotracer for **molecular imaging and diagnosis** of TLR5-expressing tumors. The antibody is labeled with radioactive iodine-131 to allow specific detection and visualization of tumor tissue via non-invasive imaging. Preclinical studies have demonstrated high tumor uptake and selectivity in animal models, making it a promising diagnostic agent for tumors with elevated TLR5 expression[2].
- Other names
- 131I-anti-TLR5 mAbradioiodinated anti-TLR5 monoclonal antibody
02
Targets
TLR5
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