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131I-SAP
- Development stage
- Preclinical
- Lead developer
- Royal Postgraduate Medical School
- Modality
- Beta Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes, Alpha Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
131I-SAP is a radiolabelled diagnostic agent composed of serum amyloid P component (SAP) tagged with iodine-131. It functions as a specific tracer for detecting and imaging amyloid deposits in systemic amyloidosis. While iodine-131 has less ideal physical characteristics for scintigraphy compared to iodine-123, its lower cost and longer half-life allow for more prolonged turnover measurements, which are valuable for monitoring disease progression and assessing treatment response over time.
- Other names
- iodine-131 labelled serum amyloid P componentiodine131 labelled serum amyloid P componentiodine 131 labelled serum amyloid P component
02
Targets
Aβ (Amyloid-beta peptides and aggregates)
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