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14C epaminurad is a radiolabeled version of epaminurad (URC102), a selective urate transporter 1 (URAT1) inhibitor developed by JW Pharmaceutical for the treatment of gout and hyperuricemia. As a uricosuric agent, epaminurad works by inhibiting the SLC22A12 transporter in the proximal tubule of the kidney, thereby preventing the reabsorption of uric acid and promoting its excretion in urine. The 14C-labeled formulation is specifically utilized in Phase 1 mass balance and metabolite profiling studies to characterize the absorption, distribution, metabolism, and excretion (ADME) of the drug in humans. While the parent compound is in Phase 3 clinical development, the 14C version is a critical tool for understanding the drug's metabolic pathways and recovery.
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