Drug intelligence / Profile preview

16-bromoepiandrosterone

Development stage
Phase 1
Lead developer
Crede Capital Group
Modality
Small Molecules
Administration
Intramuscular Injection, Buccal (buccomucosal), Oral (investigational/preclinical)
01

Overview

16-Bromoepiandrosterone is a synthetic steroid and chemical analogue of dehydroepiandrosterone (DHEA), developed as an injectable formulation. It was selected for development after demonstrating antiretroviral activity in laboratory tests. Unlike DHEA, it lacks anabolic effects but amplifies immune and metabolic responses. The compound has been investigated for its potential to limit nonproductive inflammation, enhance protective immunity, and improve survival in infections such as HIV, malaria, tuberculosis, hepatitis B and C, cytomegalovirus, polio, influenza virus, and Cryptosporidium parvum. Its mechanism involves inhibition of glucose 6-phosphate dehydrogenase (G6PDH) and modulation of androgen receptor activity; it also affects cell proliferation through complex interactions with cellular receptors[1][2][3][4][5].

Brand names
ImmunitinInactivin
Other names
16alpha-bromoepiandrosteroneInactivinEpi-Br16-Br-epi
02

Targets

AR (Adrenergic receptors)G6PD (Glucose-6-phosphate dehydrogenase)

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