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177Lu-A9-0631
- Development stage
- Preclinical
- Lead developer
- Alpha-9 Oncology
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
- Administration
- Intravenous
01
Overview
177Lu-A9-0631 is a therapeutic radiopharmaceutical developed by Alpha-9 Oncology, currently in IND-enabling studies for the treatment of breast and prostate cancers. The agent consists of a proprietary ligand, A9-0631, which specifically targets the Gastrin-Releasing Peptide Receptor (GRPR), a G protein-coupled receptor frequently overexpressed in various solid tumors. The ligand is chelated to Lutetium-177 (177Lu), a beta-emitting radioisotope that delivers localized cytotoxic radiation to tumor cells upon binding and internalization. This targeted approach aims to maximize anti-tumor efficacy while minimizing off-target toxicity to healthy tissues.
- Other names
- [177Lu]Lu-A9-0631
02
Targets
GRPR (Gastrin-releasing peptide receptor)
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