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177Lu-EDTMP

Development stage: Unknown
Lead developer: Bhabha Atomic Research Centre
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

177Lu-EDTMP is a bone-seeking radiopharmaceutical developed for the palliation of pain associated with skeletal metastases, particularly in patients with castration-resistant prostate cancer and breast cancer. It consists of the beta-emitting radioisotope Lutetium-177 complexed with the ligand ethylenediaminetetramethylene phosphonate (EDTMP). The EDTMP ligand has a high affinity for hydroxyapatite, the primary mineral component of bone, which allows the complex to selectively localize at sites of increased bone turnover typical of metastatic lesions. Once localized, Lutetium-177 delivers therapeutic beta radiation to the tumor-bone interface, alleviating pain. Additionally, its low-energy gamma emission (208 keV) allows for scintigraphic imaging and dosimetry, making it a versatile agent for both therapy and monitoring.

Other names: lutetium-177 EDTMPlutetium177 EDTMPlutetium 177 EDTMP177Lu-ethylenediaminetetramethylene phosphonatelutetium (177Lu) EDTMP

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