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177Lu-NTA-476

Development stage: Unknown
Lead developer: 3B Pharmaceuticals
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration: Intravenous

Overview

177Lu-NTA-476 is an investigational therapeutic radiopharmaceutical being developed by GenesisCare for the treatment of prostate cancer. It consists of the beta-emitting radioisotope lutetium-177 (177Lu) conjugated to NTA-476, a novel targeting ligand. The agent is part of a theranostic pair alongside its diagnostic counterpart, 68Ga-NTA-476. While the specific biological target of NTA-476 is not explicitly confirmed in public trial registrations, it is being evaluated in Phase 0 studies to assess safety, biodistribution, and radiation dosimetry in patients with prostate cancer, suggesting it targets a protein overexpressed in prostatic malignancies, such as Prostate-Specific Membrane Antigen (PSMA).

Other names: [177Lu]Lu-NTA-476Lutetium (177Lu) NTA-476

Targets

PSMA (Prostate-specific membrane antigen)

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