Drug intelligence / Profile preview

177Lu-R10306

Development stage: Unknown
Lead developer: First Affiliated Hospital of Xi'an Jiaotong University
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

177Lu-R10306 is a radiopharmaceutical consisting of the beta-emitting radioisotope Lutetium-177 (177Lu) conjugated to R10306, a ligand targeting Fibroblast Activation Protein (FAP). FAP is highly expressed on cancer-associated fibroblasts (CAFs) within the stroma of various solid tumors, including breast, lung, colorectal, and renal cancers, while showing low expression in normal tissues. This makes it an attractive target for both diagnostic imaging and targeted radionuclide therapy (theranostics). The agent is being evaluated by The First Affiliated Hospital of Xi'an Jiaotong University in Phase 1 clinical trials to assess its safety, biodistribution, and lesion detection capabilities using SPECT/CT imaging in patients with advanced solid tumors.

Other names: 177Lu-R10306[177Lu]Lu-R10306

Targets

FAP (Fibroblast activation protein alpha)

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