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177Lu-R12033

Development stage: Unknown
Lead developer: First Affiliated Hospital of Xi'an Jiaotong University
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration: Intravenous

Overview

177Lu-R12033 is an investigational therapeutic radiopharmaceutical being developed by The First Affiliated Hospital of Xi'an Jiaotong University. It consists of the beta-emitting radioisotope Lutetium-177 (177Lu) conjugated to a targeting ligand, R12033. The agent is designed for radioligand therapy in patients with advanced solid tumors, including metastatic colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC), and head and neck squamous cell carcinoma (HNSCC). It is typically studied as part of a theranostic pair alongside its Gallium-68 labeled diagnostic counterpart, 68Ga-R12033, which is used for PET/CT imaging to identify patients with sufficient target expression. Clinical evaluation focuses on the safety, biodistribution, and radiation dosimetry of the compound to determine its potential for targeted internal radiotherapy.

Other names: [177Lu]Lu-R12033

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