17alpha-picolyl-androsta-3,5-dien-17beta-ol

17alpha-picolyl-androsta-3,5-dien-17beta-ol is a synthetic heterocyclic steroidal derivative belonging to the androstane class. It features a picolyl (2-pyridylmethyl) substituent at the 17α position and a 3,5-diene system within the steroid nucleus. This compound is primarily investigated for its potent antineoplastic properties, particularly against triple-negative breast cancer (TNBC) cell lines such as MDA-MB-231. Its mechanism of action involves the induction of apoptotic cell death and the modulation of the cell cycle, leading to significant growth inhibition. As a non-hormonal steroidal agent, it is designed to bypass the need for estrogen, progesterone, or HER2 receptors, offering a potential targeted therapy for aggressive breast cancer subtypes that are resistant to conventional endocrine treatments.

Other names

17alpha-picolyl-androsta-3,5-dien-17beta-ol17α-picolyl-androsta-3,5-dien-17β-ol