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Drug intelligence / Profile preview
186Re-labeled MAb U36
- Development stage
- Unknown
- Lead developer
- Johnson & Johnson
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
**186Re-labeled MAb U36** is an investigational CD44v6-targeted radioimmunotherapy for head and neck squamous cell carcinoma. The U36 monoclonal antibody binds the variant-6 epitope of CD44 on tumor cells and delivers the beta-emitting radionuclide rhenium-186 to targeted lesions, producing localized ionizing-radiation damage. A chimeric U36 radioimmunoconjugate was evaluated intravenously in a Phase 1 study in recurrent or metastatic head and neck squamous cell carcinoma; tumor targeting was observed, while dose-limiting myelotoxicity established the maximum tolerated activity. ([jnm.snmjournals.org](https://jnm.snmjournals.org/content/41/12/1999))
- Other names
- 186Re-U36rhenium-186-labeled MAb U36rhenium186-labeled MAb U36rhenium 186-labeled MAb U36
02
Targets
CD44v6 (CD44 variant isoform 6)
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