Drug intelligence / Profile preview

188Re-NM-01

Development stage
Preclinical
Lead developer
Radiopharm Theranostics, Ltd
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Nanobodies (VHH) → Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration
Intravenous, Parenteral
01

Overview

188Re-NM-01 is a preclinical-stage therapeutic radiopharmaceutical consisting of a camelid-derived single-domain antibody (nanobody) targeting programmed death-ligand 1 (PD-L1) labeled with the beta-emitting radionuclide rhenium-188 (188Re). Originally developed by NanoMab Technology and licensed to Radiopharm Theranostics, the agent is designed to deliver targeted beta radiation directly to PD-L1-expressing tumor cells, primarily for the treatment of non-small cell lung cancer (NSCLC). By utilizing a small single-domain antibody, 188Re-NM-01 achieves rapid tumor penetration and fast blood clearance, minimizing off-target radiation exposure to healthy tissues.

Other names
188Re-NM-01 TherapeuticNM-01 TherapeuticNM01 TherapeuticNM 01 TherapeuticRhenium 188 NM 01Rhenium188 NM 01Rhenium-188 NM 01Rhenium-188 NM-01Rhenium188 NM-01Rhenium 188 NM-01
02

Targets

CD274 (Programmed cell death protein 1 ligand 1)

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