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18F-Al-NOTA-MATBBN

Development stage: Phase 1
Lead developer: The Affiliated Hospital of Jiangnan University
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration: Intravenous

Overview

18F-Al-NOTA-MATBBN is a radiopharmaceutical PET imaging agent developed by Wuxi No. 4 People's Hospital. It consists of a bombesin (BBN) analogue, MATBBN, which is conjugated to the chelator NOTA and labeled with fluorine-18 using the aluminum-fluoride (AlF) complexation method. MATBBN is a peptide designed to target the Gastrin-Releasing Peptide Receptor (GRPR), a G protein-coupled receptor that is frequently overexpressed in various cancers, including prostate and breast malignancies. By binding specifically to GRPR, the agent allows for the non-invasive visualization and localization of primary tumors and metastatic lesions via PET/CT imaging, facilitating the diagnosis, staging, and monitoring of GRPR-positive tumors.

Other names: 18F-AlF-NOTA-MATBBNFluorine-18 Aluminum NOTA-MATBBNFluorine18 Aluminum NOTA-MATBBNFluorine 18 Aluminum NOTA-MATBBN

Targets

GRPR (Gastrin-releasing peptide receptor)

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