18F-AlF-NOTA-octreotide

**18F-AlF-NOTA-octreotide** is a radiolabeled somatostatin analog used as a PET/CT imaging agent for the detection and localization of tumors expressing somatostatin receptors (SSTR), particularly neuroendocrine tumors (NETs). It consists of octreotide conjugated to NOTA (a chelator) and labeled with fluorine-18 via an aluminum fluoride complex. The drug binds with high affinity to somatostatin receptors, especially SSTR2, allowing for sensitive imaging of NETs and other SSTR-expressing lesions. Compared to traditional gallium-68-labeled analogs like [68Ga]Ga-DOTATATE/NOC, 18F-AlF-NOTA-octreotide offers logistical advantages due to the longer half-life and wider availability of fluorine-18. Clinical studies have shown it is noninferior or even superior in lesion detection rates compared to gallium-based tracers[1][5][7]. It has also been explored for localizing phosphaturic mesenchymal tumors in tumor-induced osteomalacia[8].

Other names

18F-AlF-OCAl18F-NOTA-octreotideAl-18F-NOTA-octreotideAl 18F-NOTA-octreotide