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Drug intelligence / Profile preview
18F-AlF-NOTA-pentixather
- Development stage
- Unknown
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Peptide-Drug Conjugates → Peptide Conjugates → Peptides
- Administration
- Intravenous
01
Overview
**18F-AlF-NOTA-pentixather** is a radiopharmaceutical agent used for positron emission tomography (PET) imaging. It consists of the pentapeptide pentixather, which targets the CXC chemokine receptor type 4 (CXCR4), a receptor overexpressed in various cancers and implicated in tumor growth and metastasis. The compound is labeled with fluorine-18 via an aluminum fluoride (Al^18^F) chelation to NOTA (1,4,7-triazacyclononane-triacetic acid), enabling high-resolution PET imaging. Compared to other CXCR4-targeting tracers like [68Ga]pentixafor, it offers improved affinity for CXCR4 and favorable pharmacokinetics for clinical imaging applications. Its primary use is noninvasive detection of diseases associated with CXCR4 expression such as certain lymphomas and suspected primary hyperaldosteronism[1][2][6].
- Other names
- fluorine F 18-AIF-NOTA-pentixather
02
Targets
CXCR4 (C-X-C motif chemokine receptor 4)
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