18F-BL40

18F-BL40 is a novel fluorine-18 labeled radiopharmaceutical designed as a Positron Emission Tomography (PET) imaging tracer. It specifically targets Fibroblast Activation Protein (FAP), a type II transmembrane serine protease that is highly expressed on the surface of cancer-associated fibroblasts (CAFs) within the tumor stroma of various solid malignancies, while showing minimal expression in normal tissues. By binding with high affinity to FAP, 18F-BL40 allows for the non-invasive visualization and quantification of FAP expression, which is often associated with tumor growth, invasion, and poor prognosis. This tracer is primarily being investigated for the detection, staging, and monitoring of cancers such as gastric, esophageal, and lung cancer, offering potentially superior contrast compared to traditional 18F-FDG PET in certain tumor types.

Other names

[18F]BL40fluorine-18 BL40fluorine18 BL40fluorine 18 BL4018F-labeled FAP inhibitor BL40