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18F-C27
- Development stage
- Unknown
- Lead developer
- National University of Singapore
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
18F-C27 is a fluorine-18 (18F) radiolabeled small-molecule fibroblast activation protein (FAP) inhibitor developed for positron emission tomography (PET) imaging. It consists of the small-molecule FAP inhibitor C27 conjugated to a NOTA chelator and radiolabeled with fluorine-18. FAP is highly and selectively expressed in the stroma of various epithelial cancers, particularly on cancer-associated fibroblasts (CAFs), while showing minimal expression in normal tissues. 18F-C27 PET/CT imaging is being evaluated as a diagnostic tool for the detection, staging, and monitoring of solid tumors, such as lung cancer, demonstrating high accuracy and specificity in identifying primary lesions and metastases compared to 18F-FDG.
- Other names
- [18F]-C27[18F]C2718F-labeled C27F-18-C27F18-C27F 18-C27
02
Targets
FAP (Fibroblast activation protein alpha)
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