Drug intelligence / Profile preview

18F-CAIX

Development stage: Phase 1
Lead developer: Peking University First Hospital
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules, Peptides
Administration: Intravenous

Overview

18F-CAIX refers to fluorine-18 (18F) labeled radiopharmaceuticals targeting carbonic anhydrase IX (CAIX), which are developed as positron emission tomography (PET) imaging tracers. CAIX is a transmembrane protein that is highly overexpressed in clear cell renal cell carcinoma (ccRCC) and other hypoxic solid tumors, while showing very limited expression in normal tissues. Consequently, 18F-CAIX PET/CT imaging is being investigated as a non-invasive diagnostic tool for the detection, staging, and characterization of renal tumors and other CAIX-positive malignancies. Peking University First Hospital and other institutions have initiated clinical trials to evaluate the safety, biodistribution, and diagnostic performance of 18F-CAIX tracers in patients with renal masses or suspected renal cell carcinoma.

Other names: 18F-labeled CAIX-targeted PET tracer18F-labeled carbonic anhydrase IX-targeted PET tracer

Targets

CA9 (Carbonic anhydrase IX)

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