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18F-ER176
- Development stage
- Unknown
- Lead developer
- National Institute of Mental Health
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
18F-ER176 is a second-generation radiopharmaceutical PET tracer targeting the 18 kDa translocator protein (TSPO), which is highly expressed in activated microglia and serves as a biomarker for neuroinflammation. Developed to address the limitations of earlier TSPO tracers, 18F-ER176 exhibits high affinity and, crucially, shows minimal sensitivity to the rs6971 genetic polymorphism that affects the binding of many other TSPO ligands. This makes it a valuable tool for imaging neuroinflammatory processes in various central nervous system disorders, including Alzheimer's disease, multiple sclerosis, and traumatic brain injury.
- Other names
- [18F]ER-176Fluorine-18 ER176Fluorine18 ER176Fluorine 18 ER176
02
Targets
TSPO (Translocator Protein (18 kDa))
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