18F-FAPI-42

**18F-FAPI-42** is a radiopharmaceutical used as a positron emission tomography (PET) imaging agent that targets the fibroblast activation protein (FAP), which is overexpressed in cancer-associated fibroblasts and certain inflammatory conditions. It consists of the small molecule FAP inhibitor "FAPI-42" labeled with the radioisotope fluorine-18. The drug enables high-sensitivity imaging of tumors and fibrotic or inflamed tissues by binding specifically to FAP-expressing cells, allowing for improved detection and characterization of malignancies (including appendiceal neoplasms, pulmonary artery masses, peritoneal metastases from colorectal cancer) and systemic vasculitis. Compared to standard tracers like 18F-FDG, 18F-FAPI-42 often provides higher tumor-to-background contrast and can detect more lesions in some settings[1][2][3][6][7][8]. The optimal PET/CT image acquisition time is about one hour post-injection[2].

Other names

fluorine-18-labeled FAP inhibitor 42fluorine18-labeled FAP inhibitor 42fluorine 18-labeled FAP inhibitor 42FAPI-42FAPI42FAPI 42