Drug intelligence / Profile preview

18F-FB-RMSH-1

Development stage: Preclinical
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration: Intravenous

Overview

18F-FB-RMSH-1 is a radiofluorinated metallopeptide developed as a molecular probe for positron emission tomography (PET) imaging of tumors expressing the melanocortin 1 receptor (MC1R), particularly malignant melanoma. It is a specific isomer of the rhenium-cyclized alpha-melanocyte-stimulating hormone (alpha-MSH) analog, Ac-d-Lys-ReCCMSH(Arg(11)), labeled with fluorine-18 via N-succinimidyl-4-18F-fluorobenzoate (18F-SFB). In preclinical studies, 18F-FB-RMSH-1 demonstrated high binding affinity to MC1R and superior in vivo performance compared to its isomer 18F-FB-RMSH-2, characterized by higher tumor uptake and significantly lower accumulation in the kidneys and liver. This profile makes it a promising candidate for the non-invasive detection and monitoring of MC1R-positive malignancies.

Other names: 18F-FB-Ac-d-Lys-ReCCMSH(Arg(11))18F-FB-RMSH118F-labeled metallopeptide RMSH-1

Targets

MC1R (Melanocortin Type 1 Receptor)

Beyond the preview

Go deeper on 18F-FB-RMSH-1.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on 18F-FB-RMSH-1.

Explore the full profile