18F-FluorApoTrace

18F-FluorApoTrace (also referred to as 18F-FAT) is a radiopharmaceutical PET imaging agent designed to detect apoptosis in vivo by targeting activated caspase-3, a key executioner enzyme in the apoptotic pathway. It is used primarily as a diagnostic tool in oncology clinical trials to assess treatment response by visualizing tumor cell death following chemotherapy or targeted therapies. The tracer enables non-invasive imaging of apoptosis, which can provide early indications of therapeutic efficacy before changes in tumor size are apparent. The compound has been investigated particularly for use in lymphoma and other cancers where apoptosis is an important mechanism of action for standard treatments[3]. **Developers:** Washington University School of Medicine