18F-fluoroglucaric acid

**18F-fluoroglucaric acid** is an experimental **radiopharmaceutical** PET imaging tracer designed to detect **tissue necrosis**. It is a small-molecule fluorine-18 labeled glucaric acid derivative, reported to be prepared by one-step oxidation of **18F-fluorodeoxyglucose**. Preclinical studies indicate that it accumulates in necrotic tissue by binding exposed intracellular nuclear components, particularly **histones**, after loss of membrane integrity. The tracer has been investigated for imaging **myocardial infarction**, **tumor necrosis** as a pharmacodynamic marker of anticancer treatment response, and **ischemic stroke**. Available information suggests predominantly preclinical development, rapid body clearance with notable renal uptake, and no clearly established commercial developer, although synthesis-related TEMPO kits have been associated with Molecular Targeting Technologies.

Other names

2-deoxy-2-[18F]fluoro-d-glucaric acid18F-fluoroglucaric acid