18F-FPAMT

18F-FPAMT (O-[3-18F-fluoropropyl]-α-methyltyrosine) is a radiopharmaceutical used as a positron emission tomography (**PET**) imaging agent. It is a fluorine-18 labeled tyrosine analog that targets upregulated amino acid transport systems, particularly L-type amino acid transporter 1 (**LAT1**), which are often overexpressed in various cancers. The agent is used for tumor imaging, with evidence supporting its use in the visualization of mesothelioma and potentially brain tumors. The mechanism relies on the increased uptake of amino acid analogs by malignant cells compared to normal tissue. 18F-FPAMT exhibits high radiochemical purity, in vivo stability, and favorable tumor-to-background uptake ratios, making it a promising tool for oncological imaging[5][2][8].

Other names

18F-FPAMTF-18-FPAMTF18-FPAMTF 18-FPAMTO-[3-18F-fluoropropyl]-α-methyltyrosine