18F-FPYBF-2

18F-FPYBF-2 is a small molecule fluorine-18 labeled PET imaging tracer developed for the detection of β-amyloid plaques in the brain. A benzofuran derivative, it contains a fluoropolyethylene glycol side chain designed to enhance its pharmacokinetic properties and stability. The tracer specifically binds to the insoluble amyloid-beta deposits that characterize Alzheimer's disease (AD), allowing for visual and quantitative assessment of plaque burden through PET/CT imaging. Developed by researchers at Kyoto University, it serves as a long-lived alternative (t1/2 ≈ 110 min) to carbon-11 labeled agents like Pittsburgh Compound B (PiB), facilitating its use in medical facilities without an onsite cyclotron. Clinical studies have demonstrated its high affinity and selectivity for amyloid plaques, showing effective differentiation between Alzheimer's patients and healthy controls.

Other names

5-(5-(2-(2-(2-18F-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylpyridin-2-amine5-(5-(2-(2-(2-[18F]fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylpyridin-2-amine