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18F-MC225
- Development stage
- Unknown
- Lead developer
- University Medical Center Groningen
- Modality
- Alpha Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Beta Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
18F-MC225 is a radiopharmaceutical PET tracer developed by the Universitair Medisch Centrum Groningen (UMCG) for imaging the function of P-glycoprotein (P-gp/ABCB1) at the blood-brain barrier. P-glycoprotein is an efflux transporter that plays a critical role in protecting the brain from xenobiotics and is implicated in the clearance of amyloid-beta. 18F-MC225 acts as a substrate for P-gp, allowing for the non-invasive quantification of its transport activity using positron emission tomography. This tracer is primarily utilized in clinical research to investigate P-gp dysfunction in neurodegenerative diseases such as Alzheimer's disease and in psychiatric conditions like major depressive disorder.
- Other names
- [18F]MC225
02
Targets
ABCB1 (P-glycoprotein)
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