18F-MPPF

18F-MPPF is a **fluorine-18 labeled positron emission tomography radioligand** used to image brain **serotonin 1A receptors** in vivo. It is an arylpiperazine-based small-molecule tracer that binds selectively and reversibly to the **5-hydroxytryptamine receptor 1A**, enabling PET quantification of regional receptor distribution and binding potential rather than delivering a direct therapeutic effect. In the context provided here, it is being developed by **Hospices Civils de Lyon** as an investigational imaging agent for PET-MRI studies in **Dravet syndrome** and **drug-resistant focal epilepsy**, with the goal of characterizing serotonergic pathway abnormalities in these disorders.

Other names

fluorine-18 MPPFfluorine18 MPPFfluorine 18 MPPF4-(2-methoxyphenyl)-1-[2-(N-2-pyridinyl)-p-[18F]fluorobenzamido]ethylpiperazine