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18F-NYM124
- Development stage
- Unknown
- Lead developer
- Norroy Bioscience
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
18F-NYM124 is a novel, small-molecule radiopharmaceutical designed for positron emission tomography (PET) imaging of carbonic anhydrase IX (CAIX)-expressing tumors. Developed by Norroy Bioscience, the tracer is primarily being evaluated for the non-invasive detection, staging, and characterization of clear cell renal cell carcinoma (ccRCC) and indeterminate renal masses. Carbonic anhydrase IX is a tumor-associated antigen highly overexpressed in ccRCC due to hypoxia-inducible factor (HIF) pathway activation. By targeting CAIX with high affinity, 18F-NYM124 enables high-contrast molecular imaging with favorable tumor-to-background ratios and rapid systemic clearance, offering a potential diagnostic alternative or complement to conventional 18F-FDG PET/CT.
- Other names
- [18F]F-NYM124[18F]NYM124
02
Targets
CA9 (Carbonic anhydrase IX)
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