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18F-P3BZA
- Development stage
- Unknown
- Lead developer
- Xiamen University
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
18F-P3BZA is a fluorine-18 labeled benzamide derivative developed as a positron emission tomography (PET) radiotracer for the specific imaging of malignant melanoma. It functions by targeting melanin, a pigment produced by melanocytes that is highly concentrated in most melanoma tumors. The tracer exhibits high binding affinity and specificity for melanin, allowing for the detection of both primary tumors and metastatic lesions with high contrast. Compared to the standard 18F-FDG PET, 18F-P3BZA offers improved specificity for melanin-positive tissues, potentially reducing false positives associated with inflammation. It has been evaluated in clinical trials for staging and monitoring treatment response in melanoma patients.
- Other names
- N-(2-(diethylamino)ethyl)-4-(2-[18F]fluoroethoxy)-5-iodo-2-benzamideFluorine-18 P3BZAFluorine18 P3BZAFluorine 18 P3BZA
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