18F-PSMA-11

18F-PSMA-11 is a radiopharmaceutical diagnostic agent used in Positron Emission Tomography (PET) imaging. It consists of the PSMA-11 ligand (a small-molecule peptidomimetic) labeled with the radioisotope Fluorine-18. The ligand binds with high affinity to the extracellular domain of Prostate-Specific Membrane Antigen (PSMA), also known as Glutamate Carboxypeptidase II (GCPII), which is highly overexpressed in prostate cancer cells and the neovasculature of various other solid tumors, including iodine-refractory thyroid cancer. Compared to the Gallium-68 labeled version (68Ga-PSMA-11), 18F-PSMA-11 offers superior imaging characteristics, such as a longer half-life (~110 minutes) and shorter positron range, which translates to better spatial resolution and the feasibility of centralized production and regional distribution. It is primarily employed for the primary staging of high-risk prostate cancer and the localization of recurrence in patients with rising PSA levels (biochemical recurrence).

Other names

Fluorine-18 PSMA-11Fluorine18 PSMA-11Fluorine 18 PSMA-1118F-labeled PSMA-11[18F]PSMA-1118F-HBED-CC-PSMA