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18F-S16
- Development stage
- Phase 1
- Lead developer
- Tianjin Medical University General Hospital
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
18F-S16 is a novel radiopharmaceutical PET imaging agent designed as a tau tracer for the in vivo visualization of tau protein aggregates in the brain. It is labeled with fluorine-18 and used primarily for research and diagnostic purposes in neurodegenerative diseases, particularly Alzheimer's disease. The compound demonstrates favorable biodistribution, high anti-defluorination stability, and is mainly excreted via the hepatic–biliary system. In clinical studies, 18F-S16 showed higher uptake in cortical regions of Alzheimer's disease patients compared to healthy controls, correlating with areas of abnormal tau accumulation. The agent has been found to be safe and well tolerated in human subjects[5].
- Other names
- [18F]-S16F-18 S16F18 S16F 18 S16
02
Targets
4R tau (Microtubule-associated protein tau (cis-pT231 conformation))
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